Evidence of allosteric conformational changes in the antibody constant region upon antigen binding
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چکیده
منابع مشابه
Evidence of allosteric conformational changes in the antibody constant region upon antigen binding.
We have addressed the question of whether antigen binding induces a conformational change in the heavy chain constant (C(H)) domain of antibodies using staphylococcal protein A or streptococcal protein G as probes, since these proteins are known to bind to IgG domains such as C(H)1 and C(H)2-C(H)3 domains. Biosensor assays on interactions between these proteins and mouse IgG specific to (4-hydr...
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ژورنال
عنوان ژورنال: International Immunology
سال: 2003
ISSN: 1460-2377
DOI: 10.1093/intimm/dxg036